Early changes of lung function and structure in an elastase model of emphysema—a hyperpolarized He MRI study
نویسندگان
چکیده
Kiarash Emami, Robert V. Cadman, John M. Woodburn, Martin C. Fischer, Stephen J. Kadlecek, Jianliang Zhu, Stephen Pickup, Richard A. Guyer, Michelle Law, Vahid Vahdat, Michael E. Friscia, Masaru Ishii, Jiangsheng Yu, Warren B. Gefter, Joseph B. Shrager, and Rahim R. Rizi Department of Radiology and Division of Thoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland; and Veterans Affairs Medical Center Hospital, Philadelphia, Pennsylvania
منابع مشابه
Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study.
Early changes of lung function and structure were studied in the presence of an elastase-induced model of emphysema in 35 Sprague-Dawley rats at mild (5 U/100 g) and moderate (10 U/100 g) severities. Lung ventilation was measured on a regional basis (at a planar resolution of 3.2 mm) by hyperpolarized 3He MRI at 5 and 10 wk after model induction. Subsequent to imaging, average alveolar diameter...
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Changes in lung function and structure were studied using hyperpolarized (3)He MRI in an elastase-induced murine model of emphysema. The combined analysis of the apparent diffusion coefficient (ADC) and fractional ventilation (R) were used to distinguish emphysematous changes and also to develop a model for classifying sections of the lung into diseased and normal. Twelve healthy male BALB/c mi...
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